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Frequently Asked Questions
[ Animal Health ] [ Antibodies & Calibrators ]
Antibodies & Calibrators
Antibodies/Calibrators
Interesting facts about our products and related articles.
Apo A1 and Apo B are the non-lipid components of the fat-carrying lipoproteins
Antibodies/Calibrators
What size samples can we have for evaluation?
We can ship any size sample that you may require for evaluation. We normally
ship at no charge samples upto 10 mL of the antibodies, and upto 2 mL of the
calibrators. Any sample sizes greater than 10 mL or 2 mL, we charge at the
bulk price for the remaining volume needed for evaluation. The only other
requirement is that you pay for the shipping, and if appropriate, taxes and
duties.
Do you sell secondary antibodies?
No. We sell primary antibodies specific to human serum proteins and some
additional species. All of our antisera is goat derived, polyclonal
antisera, and monospecific.
Do you have C of A sheets on your products?
Yes, click on any catalog number on our Antibodies & Calibrators page to see and print a representative C of A.
Do you have MSDS sheets on your products?
Yes, click here to request a MSDS sheet for any of our products.
How do you ship your products?
All of our antibodies and calibrators and normal human serum is shipped in
Styrofoam containers with cool packs. Prior to shipping, the material is
thawed, filtered, and shipped as a liquid product in one liter Nalgene
bottles. in the US, the product is shipped by an overnight express air
carrier. Other arrangements can be made according to your shipping
instructions. Click here to learn more about our shipping
methods and conditions.
Do you have antibodies produced to other species?
No, our antibodies are produced only in goats. We have a minimum of activity with chickens.
How big is your USDA licensed goat farm?
Our goat farm is managed by a veterinarian under all of the rules and
guidelines of the USDA. The goat farm has the capacity for upto 1200 goats.
The size of the present farm can vary from 500 goats to upto 900 goats,
depending on projects for both MBC and outside contract work.
How much antisera can you produce for me and over what time period?
We have the capacity to produce in volumes of liters to 100's of liters in
one lot size. We prefer to sell anywhere from 100 mL upto 300 liters in one
lot size. 100 plus liter single lot sizes need to be arranged in advance. We
can set aside and hold the material you need for upto 1 yr. We welcome
standing orders for extended periods.
Do you produce custom antibodies?
Yes, click here to learn more about custom antibody production.
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Interesting facts about our products and related articles.
Internet articles are provided for information only and are not endorsed nor sponsored by MBC.
Immunoglobulin A
Internet Article: Selective IgA Deficiency IDF, Family Handbook, Chapter IV
Concentrated in body fluids such as tears, saliva, and secretions of the respiratory and gastrointestinal tract.
Guards the entrances to the body and helps fight off colds.
Immunoglobulin E
Responsible for the symptoms of allergy; it causes the body to produce histamines during an allergy attack.
Levels are high in people who suffer from asthma whether the asthma is related to allergies or not.
Immunoglobulin G
A measure of reactive sulfur groups of IgG is a sensitive tumor marker discriminating different stages of breast cancer.
Efficiently coats microorganisms, speeding up their uptake by other cells in the immune system.
IgG has a relatively constant number of disulfide bonds to free sulfhydryl groups in their molecular structures.
The total amount of disulfide bonds and sulfhydryl groups (sigma-S) in IgG has now been found to correlate with the progression of breast cancer.
Immunoglobulin M
Remains in the blood stream where it is effective at killing bacteria.
Early diagnosis of Hepatitis B Virus infection in adults is able to be made by testing levels of IgM antibody to hepatitis core antigen.
IgM 1st to be produced by the body when challenged by an antibody.
Apolipoprotein A1
The major protein of high-density lipoprotein (HDL).
Association between increased HDL and a reduced incidence of coronary artery disease.
Moderate alcohol consumption increases HDL levels.
Apolipoprotein B
The major protein of low-density lipoprotein (LDL).
Elevation of LDL is a major risk factor for cardiovascular disease in adults test by checking levels of Apo B.
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Apo A1 and Apo B are the non-lipid components of the fat-carrying lipoproteins
Apolipoprotein E
Carriers of the e4 allele of the Apo E gene have a 2 fold to 5 fold higher risk of developing late onset Alzheimer’s Disease.
Lipoprotein (a)
Lipoprotein particles made up of a disulfide-linked Apo B and Apo (a).
Been associated with athersclerotic cardiovascular disease.
It is an independent and important risk factor for coronary heart disease.
Some studies show high levels of Lp(a) levels with myocardial infarction (MI).
Albumin
A negative acute phase hepatic protein distributed throughout the tissues and fluids of the body.
An antioxidant, which protects against the oxidation process, involved in the mutations that affect carcinogenesis.
Higher levels of albumin may protect against the development of colon cancer.
Low Alb. Levels associated with liver and kidney disease, inflammation, chronic illness, trauma, poor physical function and other problems.
a-1 Acid Glycoprotein
A compound consisting of a cell surface protein linked to a complex sugar.
Levels are linked to cancer.
With the more advanced stages of cancer, levels of serum glycoproteins increase.
Measures of glyco levels might serve as a useful early detection test. In addition, some measurements may aid in staging the extent of the cancer.
a-1 Anti-Trypsin
Compound of carbohydrates and protein.
Protein in the blood that is produced by the liver.
Inhibits proteolytic or protein degrading enzymes. Such as antiprotease which is what causes emphysema.
Acts to prevent trypsin from breaking down proteins.
Anti-Thrombin III
Inactivates thrombin (which activates platelet cells to clump and to change fibrinogen into fibrin – the solid protein portion of a clot).
A thrombin-anti-thrombin complex is formed (T-A-T).
T-A-T is a sensitive marker for coagulation process.
T-A-T levels increase with people who have blood pressure complications.
b-2 Microglobulin
Light chain moiety of class I Histocompatibility leukocyte antigen.
Belongs to b-globulin family of human plasma proteins.
Found in cell surface of all nucleated cells.
Elevated levels found in patients with a viral disease (HIV, Cancer, Autoimmune Diseases).
May be used as a marker for HIV infection.
Levels correlate with CD4 count, AIDs onset and death, reach peak before death.
Higher b-2 Micro levels = increased risk of disease progression.
Lower levels = less risk of developing AIDs.
Complement C3 & C4
Group of proteins in the blood that are involved in various inflammatory and immune responses.
Destroys bacteria and other foreign cells.
Levels increase with Crohn’s Disease.
When there is an immune response in which antigens combine with antibodies it initiates the activity of the compliment proteins.
C-Reactive Protein
Internet Article: Inflammation, Heart Disease and Stroke: The role of C-Reactive Protein by the American Heart Association
Acute Phase proteins.
Marker for diagnosing and monitoring a variety of diseases involving infection, inflammation and tissue necrosis.
Levels rise after onset of infection.
A marker for cardiovascular disease, CRP levels increase and the increase isn’t associated to an acute phase reaction
Levels provide a prediction of future CVD events in middle-aged men and the elderly (can’t in middle-aged women).
Levels are higher in people who smoke.
Fibronectin
Protein involved in the clearance of particle-like matter, such as cell debris, clumps of fibrin and degraded proteins.
Diverse biological effects on cell adhesion, wound healing and blood clotting.
A marker of the disruption of the chorionic-decidual interface.
Checking the levels of fetal Fibronectin may be useful for predicting pre-term delivery.
Effective supplement for the treatment of severe malnutrition because it increases other blood protein levels.
Myoglobin
Pigmented protein in the skeletal muscle that serves as an oxygen carrier.
Increased levels in the blood can provide reliable early detection for myocardial infarction.
Large amounts in systemic circulation can cause acute renal failure.
Prealbumin
Protein that is primarily made in the liver and can be detected in the blood.
Present in carcinoid tumors.
Testing for presence of prealbumin is a useful method for diagnosing lung carcinoid tumors.
Serum Amyloid A Component
An acute phase reactant.
Levels increase with disease severity.
Elevated concentrations correlated with disease outcome: higher concentration = poorer prognosis.
Can be a prognostic value for patients with unstable angina.
Serum Amyloid P Component
An acute phase reactant protein found in normal blood.
Radioactive serum amyloid P (SAP) is a useful method for detecting amyloid deposits.
Levels are relatively constant during acute inflammatory conditions.
Transferrin
A hepatic protein involved in the binding and transporting of iron in the serum.
Negative acute phase protein
Associated with Parkinson’s Disease because patients have iron metabolism defect.
PD patients have reduced serum iron, transferrin and transferrin receptors.
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